![]() Lipofuscin is commonly found at autopsy in elderly patients. Grossly, an excess of lipofuscin produces a brown discoloration, hence the term brown atrophy. ![]() Lipofuscin is the end product of free radical injury of cells and autophagy (destruction of cell organelles and structural proteins in cells undergoing atrophy). The brown pigment noted in the hepatocytes (arrow) represents lipofuscin (wear and tear pigment). Liver biopsy: lipofuscin Please support this website by 1, 3 or 5 $$ The skin is cyanotic, however the mucous membranes are pink. Peripheral cyanosis refers to vasoconstriction of the blood vessels in the skin with central shunting of the blood (e.g., hypothermia). ![]() Heart disease), since a low arterial PO 2 automatically lowers the amount of O 2 that diffuses
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